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Applications are invited from potential postdoctoral researchers to work in Hari Hundal’s lab in the Division of Cell Signalling & Immunology on a Diabetes UK funded project investigating the impact of fatty acid availability on mitochondrial biology and cellular inflammation.  


It is well established that cell and tissue function is critically dependent upon mitochondrial energy homeostasis. However, under circumstances of continual nutrient (caloric) excess mitochondrial function is compromised resulting in metabolic dysfunction, which has been linked to development of inflammation and insulin resistance in tissues such as skeletal muscle.  This research project aims to understand (i) how mitochondrial insufficiency induced by lipid (fatty acid) overload contributes to increased inflammatory signalling and insulin resistance in muscle cells, (ii) how inflammatory signalling may potentiate mitochondrial dysfunction and (iii) how impaired mitochondrial function and proinflammatory signalling induced by fuel oversupply can be mitigated to improve skeletal muscle insulin sensitivity.


The project ideally requires an individual with research interests in the area of cell signalling/cellular metabolism with prior experience of molecular biological, cell culture and basic microscopy/proteomic techniques. The successful candidate will also be someone with an excellent track record who is self-motivated, well-organized, highly independent, and possesses good interpersonal skills.


The position is full-time and available for 3 years and will suit applicants early in their postdoctoral career, but candidates in their final year of Ph.D. with a strong publication record (and at least one first authored) are welcome to apply. A detailed CV with the names and contact information of three academic referees should accompany the application.


Informal enquiries are welcome and should be directed to Professor Hari Hundal: (01382) 384969


Appointment as a Postdoctoral Research Assistant on the Grade 7 (£31,076 - £33,943 per annum, dependent on experience) / Grade 7 Training (£27,629 - £30,175 for candidates who have submitted their PhD thesis and await viva examination.

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